Publikationen

Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A, Odoardi F. Distinct roles of the meningeal layers in CNS autoimmunity, Nat Neurosci 2022 Jul;25(7):887-899,  http://dx.doi.org/10.1038/s41593-022-01108-3 (Pubmed)

Sudhakar Reddy Kalluri,Rajneesh Srivastava, Selin Kenet, Goutam K. Tanti, Klaus Dornmair, Jeffrey L. Bennett, Thomas Misgeld, Bernhard Hemmer, Matthias T. Wyss & Marina Herwerth . P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica. Neurotherapeutics (2022). https://doi.org/10.1007/s13311-022-01269-w (Pubmed)

Laura Empl, Alexandra Chovsepian, Maryam Chahin, Wing Yin Vanessa Kan, Julie Fourneau, Valérie Van Steenbergen, Sanofer Weidinger, Maite Marcantoni, Alexander Ghanem, Peter Bradley, Karl Klaus Conzelmann, Ruiyao Cai, Alireza Ghasemigharagoz, Ali Ertürk, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Sabine Liebscher & Florence M. Bareyre , Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury. Nat Commun 13, 2659 (2022). https://doi.org/10.1038/s41467-022-29992-0 (Pubmed)

Vincenti I, Page N, Steinbach K, Yermanos A, Lemeille S, Nunez N, Kreutzfeldt M, Klimek B, Di Liberto G, Egervari K, Piccinno M, Shammas G, Mariotte A, Fonta N, Liaudet N, Shlesinger D, Liuzzi AR, Wagner I, Saadi C, Stadelmann C, Reddy S, Becher B, Merkler D. Tissue-resident memory CD8⁺ T cells cooperate with CD4⁺ T cells to drive compartmentalized immunopathology in the CNS. Sci Transl Med. 2022 Apr 13;14(640):eabl6058. doi: 10.1126/scitranslmed.abl6058.  (Pubmed)

Asadollahi E, Trevisiol A, Saab AS, et al. Myelin lipids as nervous system energy reserves. bioRxiv; 2022. DOI: 10.1101/2022.02.24.481621. (Pubmed)

Bocchi R, Masserdotti G, Götz M. Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches. Neuron. 2022 Feb 2;110(3):366-393. (Pubmed)

Bauer A, Puglisi M, Nagl D, Schick JA, Werner T, Klingl A, El Andari J, Hornung V, Kessler H, Götz M, Grimm D, Brack-Werner R. Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. Adv Sci (Weinh). 2022 Apr 10:e2104979. (Pubmed)

Fourneau J, Bareyre FM. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural Regen Res. 2022 May;17(5):959-962. (Pubmed)

Aljovic A, Zhao S, Chahin M, de la Rosa C, Van Steenbergen V, Kerschensteiner M,  Bareyre FM. A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders. Commun Biol. 2022 Feb 15;5(1):131. (Pubmed)

Ehrenreich H, Garcia-Agudo LF, Steixner-Kumar AA, Wilke JBH, Butt UJ. Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance. Mol Psychiatry. 2022 Apr 12:1–8.  (Pubmed)

Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nat Commun. 2022 Mar 4;13(1):1163. (Pubmed)

Sanchez-Gonzalez R, Koupourtidou C, Lepko T, Zambusi A, Novoselc KT, Durovic T, Aschenbroich S, Schwarz V, Breunig CT, Straka H, Huttner HB, Irmler M, Beckers J, Wurst W, Zwergal A, Schauer T, Straub T, Czopka T, Trümbach D, Götz M, Stricker SH, Ninkovic J. Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 2022 Feb 2;11(3):520. (Pubmed)

Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Tsaktanis T, Naumann U, Rothhammer V. Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation. Front Immunol. 2022 Jan 3;12:800128. (Pubmed)

Linnerbauer M, Lößlein L, Vandrey O, Tsaktanis T, Beer A, Naumann UJ, Panier F, Beyer T, Nirschl L, Kuramatsu JB, Winkler J, Quintana FJ, Rothhammer V. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation. JCI Insight. 2022 Apr 8;7(7):e154824. (Pubmed)

Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA. Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation. Front Cell Dev Biol. 2021 Nov 8;9:747699. (Pubmed)

Wang M, Misgeld T, Brill MS. Neural labeling and manipulation by neonatal intraventricular viral injection in mice. STAR Protoc. 2022 Jan 10;3(1):101081. (Pubmed)

Khalin I, Adarsh N, Schifferer M, Wehn A, Groschup B, Misgeld T, Klymchenko A, Plesnila N. Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury. Small. 2022 Apr 5:e2200302. (Pubmed)

Mar Bosch-Queralt, Vini Tiwari, Alkmini Damkou, Lenka Vaculčiaková, Ioannis Alexopoulos, Mikael Simons. A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain, STAR Protocols, Volume 3, Issue 1, 2022. (Pubmed)

Leon Hosang, Roger Cugota Canals, Felicia Joy van der Flier, Jacqueline Hollensteiner, Rolf Daniel, Alexander Flügel & Francesca Odoardi, The lung microbiome regulates brain autoimmunity. Nature 603, 138–144 (2022). (Pubmed)

Lilian Aly, Christina Noll, Rebecca Wicklein, Elisabeth Wolf, Eva Feodora Romahn, Josphine Wauschkuhn, Sami Hosari, Christian Mardin, 
Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier. Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis, , Neurol Neuroimmunol Neuroinflamm May 2022, 9 (3) e1159. (Pubmed)

Zhu J, Cao J, Liesz A, Roth S. A macrophage-T cell coculture model for severe tissue injury-induced T cell death. STAR Protoc. 2021 Dec 1;2(4):100983. doi: 10.1016/j.xpro.2021.100983. (Pubmed)

Zhang Y, Liesz A, Li P. Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke. Stroke. 2021 Dec;52(12):e837-e841. doi: 10.1161/STROKEAHA.121.036072. (Pubmed)

Korn T, Hiltensperger M. Role of IL-6 in the commitment of T cell subsets. Cytokine. 2021 Oct;146:155654. doi: 10.1016/j.cyto.2021.155654. (Pubmed)

Aly L, Strauß EM, Feucht N, Weiß I, Berthele A, Mitsdoerffer M, Haass C, Hemmer B, Maier M, Korn T, Knier B. Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders. Mult Scler. 2022 Apr;28(4):522-531. doi: 10.1177/13524585211028831. (Pubmed)

Edgar JM, McGowan E, Chapple KJ, Möbius W, Lemgruber L, Insall RH, Nave KA, Boullerne A. Río-Hortega's drawings revisited with fluorescent protein defines a cytoplasm-filled channel system of CNS myelin. J Anat. 2021 Dec;239(6):1241-1255. doi: 10.1111/joa.13577. Epub 2021 Oct 28. (Pubmed)

Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M. Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep. 2021 Oct 26;37(4):109898. doi: 10.1016/j.celrep.2021.109898. (Pubmed)

Begemann M, Gross O, Wincewicz D, Hardeland R, Daguano Gastaldi V, Vieta E, Weissenborn K, Miskowiak KW, Moerer O, Ehrenreich H. Addressing the 'hypoxia paradox' in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues. Mol Med. 2021 Sep 26;27(1):120. doi: 10.1186/s10020-021-00381-5. (Pubmed)

Tuzlak S, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F, Korn T, Becher B. Repositioning T_H cell polarization from single cytokines to complex help. Nat Immunol. 2021 Oct;22(10):1210-1217. doi: 10.1038/s41590-021-01009-w. (Pubmed)

Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, Cantuti-Castelvetri L, Simons M. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021 Oct 4;218(10):e20210227. doi: 10.1084/jem.20210227. (Pubmed)

Fernandez Garcia-Agudo L, Steixner-Kumar AA, Curto Y, Barnkothe N, Hassouna I, Jähne S, Butt UJ, Grewe K, Weber MS, Green K, Rizzoli S, Nacher J, Nave KA, Ehrenreich H. Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell Rep. 2021 Aug 24;36(8):109548. doi: 10.1016/j.celrep.2021.109548. (Pubmed)

Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, Nave KA, Lühder F, Ehrenreich H. Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis. Mol Psychiatry. 2021 Dec;26(12):7746-7759. doi: 10.1038/s41380-021-01238-3. (Pubmed)

Van Steenbergen V, Bareyre FM. Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury. Exp Neurol. 2021 Nov;345:113839. doi: 10.1016/j.expneurol.2021.113839. (Pubmed)

Bergner CG, Genc N, Hametner S, Franz J, van der Meer F, Mitkovski M, Weber MS, Stoltenburg-Didinger G, Kühl JS, Köhler W, Brück W, Gärtner J, Stadelmann C. Concurrent axon and myelin destruction differentiates X-linked adrenoleukodystrophy from multiple sclerosis. Glia. 2021 Oct;69(10):2362-2377. doi: 10.1002/glia.24042. (Pubmed)

Liu L, Besson-Girard S, Ji H, Gehring K, Bulut B, Kaya T, Usifo F, Simons M, Gokce O. Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing. STAR Protoc. 2021 Jun 10;2(2):100590. doi: 10.1016/j.xpro.2021.100590. (Pubmed)

Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. (Pubmed)

Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I. Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life Sci Alliance. 2021 Dec 21;5(3):e202101185. (Pubmed)

Brüser C, Keller-Findeisen J, Jakobs S. The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels. Cell Rep. 2021 Nov 23;37(8):110000. (PubMed) 

Arinrad S, Wilke JBH, Seelbach A, Doeren J, Hindermann M, Butt UJ, Steixner-Kumar AA, Spieth L, Ronnenberg A, Pan H, Berghoff SA, Hollmann M, Lühder F, Nave KA, Bechter K, Ehrenreich H. NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance. Mol Psychiatry. 2021 Dec 6. (PubMed) 

Jesus Gil-Pulido, Núria Amézaga, Ivana Jorgacevic, Helga D Manthey, Melanie Rösch, Theresa Brand, Peter Cidlinsky, Sarah Schäfer, Andreas Beilhack, Antoine-Emmanuel Saliba, Kristina Lorenz, Louis Boon, Immo Prinz, Ari Waisman, Thomas Korn, Clément Cochain, Alma Zernecke, Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice, Cardiovascular Research, Dec 2021;, cvab359 (PubMed) 

Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021 Nov 11;12(1):6530. (PubMed) 

Peter Engerer, Eleni Petridou, Philip R. Williams, Sachihiro C.Suzuki, TakeshiYoshimatsu, Ruben Portugues, Thomas Misgeld, Leanne Godinho. Notch-mediated re-specification of neuronal identity during central nervous system development, Current Biology. Volume 31, Issue 21, 2021, Pages 4870-4878.e5, PMID: 34534440, DOI: 10.1016/j.cub.2021.08.049 (PubMed)