{"id":4062,"date":"2024-09-27T11:29:00","date_gmt":"2024-09-27T09:29:00","guid":{"rendered":"https:\/\/www.sfb274.de\/?p=4062"},"modified":"2025-03-10T12:06:39","modified_gmt":"2025-03-10T11:06:39","slug":"twin-study-cd8-cells-progression","status":"publish","type":"post","link":"https:\/\/www.sfb274.de\/en\/twin-study-cd8-cells-progression\/","title":{"rendered":"CD8+ T cells drive inflammation in both prodromal and established MS"},"content":{"rendered":"<div class=\"gb-container gb-container-e933a9a0\">\n\n<p>Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression.<br><br>Using single-cell RNA sequencing and T cell receptor analysis, scientists compared immune cells from identical twins, where one twin showed no symptoms or only early signs of neuroinflammation.<br><br><strong><mark style=\"background-color:var(--global-palette8)\" class=\"has-inline-color\">CD8+ T cells in people with MS show unique changes that make them more migratory, highly activated, and pro-inflammatory. These changes were also seen in twins with subclinical neuroinflammation, indicating that these immune cells may already drive disease in its earliest stages.<\/mark><\/strong><br><br>Read the full article published in Science Immunology <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adj8094\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>.<\/p>\n\n<\/div>\n\n\n<p>TRR 274 Project leaders contributing to this project: <strong>Martin Kerschensteiner<\/strong> (<a href=\"https:\/\/www.sfb274.de\/en\/project\/b07\/\">B07<\/a>, <a href=\"https:\/\/www.sfb274.de\/en\/project\/c02\/\">C02<\/a>) and <strong>Thomas Korn<\/strong> (<a href=\"https:\/\/www.sfb274.de\/en\/project\/a01\/\">A01<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression. Using single-cell RNA sequencing and T cell receptor analysis, scientists compared immune cells from identical twins, where one twin showed no symptoms or only early signs of neuroinflammation. CD8+ T cells in people&#8230;<\/p>\n","protected":false},"author":6,"featured_media":4064,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[33],"class_list":["post-4062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CD8+ T cells drive inflammation in both prodromal and established MS - SFB-Transregio 274<\/title>\n<meta name=\"description\" content=\"CD8+ T cells in people with MS show unique changes that make them more migratory, highly activated, and pro-inflammatory.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sfb274.de\/en\/twin-study-cd8-cells-progression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CD8+ T cells drive inflammation in both prodromal and established MS - 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