{"id":6664,"date":"2026-09-16T14:56:02","date_gmt":"2026-09-16T12:56:02","guid":{"rendered":"https:\/\/www.sfb274.de\/?p=6664"},"modified":"2026-10-19T15:04:06","modified_gmt":"2026-10-19T13:04:06","slug":"anti-cd40l-prevents-meningeal-b-cell-aggregates-and-mitigates-progressive-autoimmune-encephalomyelitis","status":"publish","type":"post","link":"https:\/\/www.sfb274.de\/en\/anti-cd40l-prevents-meningeal-b-cell-aggregates-and-mitigates-progressive-autoimmune-encephalomyelitis\/","title":{"rendered":"Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Background<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Progressive multiple sclerosis (MS) remains difficult to treat, in part because chronic inflammation persists within the central nervous system (CNS). Meningeal tertiary lymphoid structures (TLS), organised immune-cell aggregates in the meninges, are thought to contribute to sustained neuroinflammation and disease progression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Aims<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study investigated whether blocking CD40 ligand (CD40L), a key regulator of immune-cell interactions, could disrupt meningeal TLS and ameliorate progressive disease in a chronic mouse model of MS.<\/p>\n\n\n\n<div class=\"wp-block-group has-theme-palette-8-background-color has-background\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><strong>Key Findings<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Systemic anti-CD40L treatment eliminated meningeal TLS in the chronic mouse model.<\/li>\n\n\n\n<li>Treatment halted disease progression and reduced CNS inflammation.<\/li>\n\n\n\n<li>Anti-CD40L therapy induced sustained changes in CNS antigen-presenting cells, suggesting a broader and durable impact on the local immune environment.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Implications<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These findings identify CD40L-mediated immune interactions as a potential therapeutic target for progressive MS. By disrupting organised meningeal inflammation and reshaping CNS immune responses, CD40L blockade may offer a complementary strategy to existing treatments. Further research is needed to establish its safety and efficacy in humans<\/p>\n\n\n\n<ul class=\"wp-block-list\"><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Conclusion<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Targeting CD40L offers a promising therapeutic strategy to combat chronic meningeal inflammation and halt disease progression in a mouse model of progressive MS. By eliminating meningeal TLS and durably reshaping CNS immune responses, this approach highlights the potential of targeting immune-cell interactions to address compartmentalised inflammation that remains difficult to control with existing therapies. Further studies are needed to determine its translational potential for progressive MS in humans.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Full text for further details:<\/strong> <a href=\"https:\/\/doi.org\/10.1038\/s41590-025-02416-z\" target=\"_blank\" rel=\"noreferrer noopener\">Brain<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TRR 274 Project leaders contributing to this project:&nbsp;<strong>Thomas Korn (<a href=\"https:\/\/www.sfb274.de\/en\/project\/a01\/\">A01<\/a>).<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background Progressive multiple sclerosis (MS) remains difficult to treat, in part because chronic inflammation persists within the central nervous system (CNS). Meningeal tertiary lymphoid structures (TLS), organised immune-cell aggregates in the meninges, are thought to contribute to sustained neuroinflammation and disease progression. Aims The study investigated whether blocking CD40 ligand (CD40L), a key regulator of&#8230;<\/p>\n","protected":false},"author":6,"featured_media":6670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[33],"class_list":["post-6664","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Anti-CD40L prevents 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