{"id":2421,"date":"2024-01-30T14:19:28","date_gmt":"2024-01-30T13:19:28","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2421"},"modified":"2024-09-18T17:52:34","modified_gmt":"2024-09-18T15:52:34","slug":"a01","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/a01\/","title":{"rendered":"CD96 as checkpoint for the persistence of T cell responses in the central nervous system"},"content":{"rendered":"<style>.kb-row-layout-id2421_d5ebc6-bc > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2421_d5ebc6-bc > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2421_d5ebc6-bc > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2421_d5ebc6-bc > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2421_d5ebc6-bc > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2421_d5ebc6-bc > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2421_d5ebc6-bc alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col,.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col{flex-direction:column;}.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2421_3b2dd2-6a{position:relative;}@media all and (max-width: 1024px){.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2421_3b2dd2-6a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2421_3b2dd2-6a\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>Compartmentalized inflammatory processes within the CNS might be a driver of tissue damage in chronic stages of CNS autoimmunity. Tissue resident T cells constitute a sizeable population of immune cells in the chronically inflamed CNS. However, little is known about their functional integration into CNS tissue niches. Here, we have identified the co-inhibitory molecule CD96 to be expressed on a subset of CNS resident conventional and regulatory T cells. Using genetic tools, we aim to investigate the interaction of CD96 with its CNS-expressed ligands and interrogate its function as a checkpoint to control perpetuation vs resolution of CNS resident T cell populations in the chronically inflamed CNS.<\/p>\n\n\n\n<p class=\"has-theme-palette-7-color has-text-color has-link-color wp-elements-99222f824c93ec704bc5248ddeaa75d1\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/434443429\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2421_ea0d14-93 > .kt-inside-inner-col,.kadence-column2421_ea0d14-93 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2421_ea0d14-93 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2421_ea0d14-93 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2421_ea0d14-93 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2421_ea0d14-93 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2421_ea0d14-93{position:relative;}@media all and (max-width: 1024px){.kadence-column2421_ea0d14-93 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2421_ea0d14-93 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2421_ea0d14-93\"><div class=\"kt-inside-inner-col\"><style>.kb-image2421_b54b14-1c .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image2421_b54b14-1c\"><figure class=\"alignright size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"823\" height=\"720\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-823x720.png\" alt=\"CD96 as checkpoint for the persistence of T cell responses in the central nervous system.\" class=\"kb-img wp-image-2376\" title=\"\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-1536x1344.png 1536w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2.png 1890w\" sizes=\"auto, (max-width: 823px) 100vw, 823px\" \/><\/figure><\/div>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2421_de4c5d-01 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2421_de4c5d-01 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2421_de4c5d-01 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2421_de4c5d-01 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2421_de4c5d-01 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2421_de4c5d-01 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2421_de4c5d-01 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2421_2990a7-ca > .kt-inside-inner-col,.kadence-column2421_2990a7-ca > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2421_2990a7-ca > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2421_2990a7-ca > .kt-inside-inner-col{flex-direction:column;}.kadence-column2421_2990a7-ca > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2421_2990a7-ca > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2421_2990a7-ca{position:relative;}@media all and (max-width: 1024px){.kadence-column2421_2990a7-ca > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2421_2990a7-ca > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2421_2990a7-ca\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-right\"><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2421_8df83d-47 > .kt-inside-inner-col,.kadence-column2421_8df83d-47 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2421_8df83d-47 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2421_8df83d-47 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2421_8df83d-47 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2421_8df83d-47 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2421_8df83d-47{position:relative;}@media all and (max-width: 1024px){.kadence-column2421_8df83d-47 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2421_8df83d-47 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2421_8df83d-47\"><div class=\"kt-inside-inner-col\">\n<p><a href=\"https:\/\/www.sfb274.de\/en\/project\/multicellular-interactions-of-microglia\/\">Next Project  >><\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p><\/p>\n","protected":false},"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false},"project-area":[20],"class_list":["post-2421","project","type-project","status-publish","hentry","project-area-a-immunological-checkpoints-of-cns-recovery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CD96 as checkpoint for the persistence of T cell responses in the central nervous system - SFB-Transregio 274<\/title>\n<meta name=\"description\" content=\"We aim to investigate the interaction of CD96 with its ligands as a checkpoint of perpetuation vs resolution in the chronically inflamed CNS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sfb274.de\/en\/project\/a01\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CD96 as checkpoint for the persistence of T cell responses in the central nervous system - SFB-Transregio 274\" \/>\n<meta property=\"og:description\" content=\"We aim to investigate the interaction of CD96 with its ligands as a checkpoint of perpetuation vs resolution in the chronically inflamed CNS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sfb274.de\/en\/project\/a01\/\" \/>\n<meta property=\"og:site_name\" content=\"SFB-Transregio 274\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-18T15:52:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/A01-Graphical-Abstract-Korn_V2-823x720.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sfb274.de\/en\/project\/a01\/\",\"url\":\"https:\/\/www.sfb274.de\/en\/project\/a01\/\",\"name\":\"CD96 as checkpoint for the persistence of T cell responses in the central nervous system - 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