{"id":2448,"date":"2024-01-30T14:19:28","date_gmt":"2024-01-30T13:19:28","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2448"},"modified":"2024-09-20T10:31:55","modified_gmt":"2024-09-20T08:31:55","slug":"b03","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/b03\/","title":{"rendered":"Glia-glia interactions as checkpoints of antibody-mediated CNS lesion formation and resolution"},"content":{"rendered":"<style>.kb-row-layout-id2448_2ee396-08 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2448_2ee396-08 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2448_2ee396-08 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2448_2ee396-08 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2448_2ee396-08 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2448_2ee396-08 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2448_2ee396-08 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2448_2be547-5d > .kt-inside-inner-col,.kadence-column2448_2be547-5d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_2be547-5d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_2be547-5d > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_2be547-5d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_2be547-5d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_2be547-5d{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_2be547-5d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_2be547-5d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_2be547-5d\"><div class=\"kt-inside-inner-col\"><style>.kadence-column2448_cf8d14-43 > .kt-inside-inner-col,.kadence-column2448_cf8d14-43 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_cf8d14-43 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_cf8d14-43 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_cf8d14-43 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_cf8d14-43 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_cf8d14-43{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_cf8d14-43 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_cf8d14-43 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_cf8d14-43\"><div class=\"kt-inside-inner-col\"><style>.kb-image2448_5df1b6-2d .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image2448_5df1b6-2d size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"823\" height=\"720\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld-823x720.png\" alt=\"\" class=\"kb-img wp-image-2384\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld-1536x1344.png 1536w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B03-Graphical-Abstract-Stadelmann-Misgeld.png 1890w\" sizes=\"auto, (max-width: 823px) 100vw, 823px\" \/><\/figure>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column2448_af1a1a-eb > .kt-inside-inner-col,.kadence-column2448_af1a1a-eb > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_af1a1a-eb > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_af1a1a-eb > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_af1a1a-eb > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_af1a1a-eb > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_af1a1a-eb{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_af1a1a-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_af1a1a-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_af1a1a-eb\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>In autoantibody-mediated gliopathies, such as Neuromyelitis Optica Spectrum Disorder, pathology often spreads quickly beyond the intital target cell type to affect other glial cells. In this project, we will identify glial-glia interactions that act either as checkpoints of acute pathology spread or as checkpoints of lesion repair. To achieve this, we will use in vivo imaging in animal models, as well as genetic interventions and close correlation with human neuropathology, to study how the dissemination of pathology from one cell type to another could be intercepted and how lesion repair, especially remyelination, could be promoted.<\/p>\n\n\n\n<p class=\"has-text-align-right has-theme-palette-7-color has-text-color has-link-color wp-elements-74deeadb64c8f21acc66e28d30d77359\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/434472123\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(10% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(50% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)));}.kb-row-layout-id2448_18ee29-d1 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id2448_18ee29-d1 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2448_18ee29-d1 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2448_af6842-6e > .kt-inside-inner-col,.kadence-column2448_af6842-6e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_af6842-6e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_af6842-6e > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_af6842-6e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_af6842-6e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_af6842-6e{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_af6842-6e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_af6842-6e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_af6842-6e\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/www.sfb274.de\/en\/project\/b02\/\">&lt;&lt;  Previous Project<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2448_b66c72-21 > .kt-inside-inner-col,.kadence-column2448_b66c72-21 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_b66c72-21 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_b66c72-21 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_b66c72-21 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_b66c72-21 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_b66c72-21{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_b66c72-21 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_b66c72-21 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_b66c72-21\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\"><strong>|<\/strong><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2448_e894f8-e7 > .kt-inside-inner-col,.kadence-column2448_e894f8-e7 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2448_e894f8-e7 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2448_e894f8-e7 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2448_e894f8-e7 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2448_e894f8-e7 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2448_e894f8-e7{position:relative;}@media all and (max-width: 1024px){.kadence-column2448_e894f8-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2448_e894f8-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2448_e894f8-e7\"><div class=\"kt-inside-inner-col\">\n<p><a href=\"https:\/\/www.sfb274.de\/en\/project\/b05\/\">Next Project  >><\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"project-area":[19],"class_list":["post-2448","project","type-project","status-publish","hentry","project-area-b-glial-checkpoints-of-cns-recovery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Glia-glia interactions as checkpoints of antibody-mediated CNS lesion formation and resolution - SFB-Transregio 274<\/title>\n<meta name=\"description\" content=\"We will identify glial-glia interactions that 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