{"id":2451,"date":"2024-01-30T14:19:27","date_gmt":"2024-01-30T13:19:27","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2451"},"modified":"2024-09-20T10:33:09","modified_gmt":"2024-09-20T08:33:09","slug":"b05","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/b05\/","title":{"rendered":"Cross-talk between innate immunity and extracellular vesicles\u00a0(EV)\u00a0forms a checkpoint regulating long-lasting neuroinflammation after brain injury"},"content":{"rendered":"<style>.kb-row-layout-id2451_dcad79-ed > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2451_dcad79-ed > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2451_dcad79-ed > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2451_dcad79-ed > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2451_dcad79-ed > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2451_dcad79-ed > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2451_dcad79-ed alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col,.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2451_4cc9ad-a7{position:relative;}@media all and (max-width: 1024px){.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2451_4cc9ad-a7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2451_4cc9ad-a7\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Traumatic brain injuries (TBIs) cause primary tissue damage and activate glial cells to build glial border, thereby delineating the injured brain parenchyma from the healthy surrounding tissue. However, this necessary primary reaction of glial cells often persists. This long-lasting glial activation results in prolonged and exacerbated neuroinflammation that prevents tissue restoration. We propose that a cross-regulatory network between innate immunity pathways and EV cargo defines an important checkpoint that turns protective glial border cells into tissue scaring cells. We aim to identify EV cargos and their dependence on innate immunity pathways as drug-targetable molecular checkpoints to improve tissue regeneration.<\/p>\n\n\n\n<p class=\"has-theme-palette-7-color has-text-color has-link-color wp-elements-c26becc06492a5c708e07bc9abc586c3 wp-block-paragraph\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/434474182\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2451_d63a71-25 > .kt-inside-inner-col,.kadence-column2451_d63a71-25 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2451_d63a71-25 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2451_d63a71-25 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2451_d63a71-25 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2451_d63a71-25 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2451_d63a71-25{position:relative;}@media all and (max-width: 1024px){.kadence-column2451_d63a71-25 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2451_d63a71-25 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2451_d63a71-25\"><div class=\"kt-inside-inner-col\"><style>.kb-image2451_3e1758-f9 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image2451_3e1758-f9 size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"823\" height=\"720\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic-823x720.png\" alt=\"\" class=\"kb-img wp-image-2385\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic-1536x1344.png 1536w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/B05-Graphical-Abstract-Ninkovic.png 1890w\" sizes=\"auto, (max-width: 823px) 100vw, 823px\" \/><\/figure>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(50% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(10% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)));}.kb-row-layout-id2451_2f9cd3-54 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id2451_2f9cd3-54 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2451_2f9cd3-54 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2451_58d87c-34 > .kt-inside-inner-col,.kadence-column2451_58d87c-34 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2451_58d87c-34 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2451_58d87c-34 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2451_58d87c-34 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2451_58d87c-34 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2451_58d87c-34{position:relative;}@media all and (max-width: 1024px){.kadence-column2451_58d87c-34 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2451_58d87c-34 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2451_58d87c-34\"><div 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>><\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"project-area":[19],"class_list":["post-2451","project","type-project","status-publish","hentry","project-area-b-glial-checkpoints-of-cns-recovery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cross-talk between innate immunity and extracellular vesicles\u00a0(EV)\u00a0forms a checkpoint regulating long-lasting neuroinflammation after brain injury - SFB-Transregio 274<\/title>\n<meta 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