{"id":2460,"date":"2024-01-30T14:19:27","date_gmt":"2024-01-30T13:19:27","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2460"},"modified":"2024-09-20T11:10:03","modified_gmt":"2024-09-20T09:10:03","slug":"c01","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/c01\/","title":{"rendered":"EPO\/EPOR signalling in the recovery from brain injury and disease"},"content":{"rendered":"<style>.kb-row-layout-id2460_40dedf-98 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2460_40dedf-98 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2460_40dedf-98 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2460_40dedf-98 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2460_40dedf-98 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2460_40dedf-98 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2460_40dedf-98 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2460_5c414f-5c > .kt-inside-inner-col,.kadence-column2460_5c414f-5c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2460_5c414f-5c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2460_5c414f-5c > .kt-inside-inner-col{flex-direction:column;}.kadence-column2460_5c414f-5c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2460_5c414f-5c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2460_5c414f-5c{position:relative;}@media all and (max-width: 1024px){.kadence-column2460_5c414f-5c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2460_5c414f-5c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2460_5c414f-5c\"><div class=\"kt-inside-inner-col\"><style>.kb-image2460_f1ea5a-e1 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image2460_f1ea5a-e1 size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"823\" height=\"720\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2-823x720.png\" alt=\"\" class=\"kb-img wp-image-2388\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2-1536x1344.png 1536w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C01-Graphical-Abstract-Nave-Ehrenreich_V2.png 1890w\" sizes=\"auto, (max-width: 823px) 100vw, 823px\" \/><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column2460_508f15-00 > .kt-inside-inner-col,.kadence-column2460_508f15-00 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2460_508f15-00 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2460_508f15-00 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2460_508f15-00 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2460_508f15-00 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2460_508f15-00{position:relative;}@media all and (max-width: 1024px){.kadence-column2460_508f15-00 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2460_508f15-00 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2460_508f15-00\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>Erythropoietin (EPO) is a cytokine that serves, independent of hematopoiesis, signalling functions within the brain, where EPO and its receptor are upregulated upon injury. The underlying mechanisms, however, have remained obscure. We aim to understand the roles of EPO\/EPOR signalling as checkpoints of brain homeostasis and thereby specifically predict effects of recombinant EPO as a neuroprotective drug. To this end, we will explore the induction\/expression of EPO and EPOR at the single cell level with novel reporter mice and test the recovery of cell specific Epo\/Epor mutants from acute and chronic brain injury.<\/p>\n\n\n\n<p class=\"has-text-align-right has-theme-palette-7-color has-text-color has-link-color wp-elements-20d04656f353b0707a8a0960b562f6f5\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/434474935\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(10% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(50% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)));}.kb-row-layout-id2460_86a0a2-1c > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id2460_86a0a2-1c > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2460_86a0a2-1c alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2460_72f90c-fe > .kt-inside-inner-col,.kadence-column2460_72f90c-fe > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2460_72f90c-fe > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2460_72f90c-fe > .kt-inside-inner-col{flex-direction:column;}.kadence-column2460_72f90c-fe > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2460_72f90c-fe > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2460_72f90c-fe{position:relative;}@media all and (max-width: 1024px){.kadence-column2460_72f90c-fe > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2460_72f90c-fe > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2460_72f90c-fe\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/www.sfb274.de\/en\/project\/b07\/\">&lt;&lt;  Previous Project<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2460_61f22a-c5 > .kt-inside-inner-col,.kadence-column2460_61f22a-c5 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2460_61f22a-c5 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2460_61f22a-c5 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2460_61f22a-c5 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2460_61f22a-c5 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2460_61f22a-c5{position:relative;}@media all and (max-width: 1024px){.kadence-column2460_61f22a-c5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2460_61f22a-c5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2460_61f22a-c5\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\"><strong>|<\/strong><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col,.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2460_c7a5a1-39{position:relative;}@media all and (max-width: 1024px){.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2460_c7a5a1-39 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2460_c7a5a1-39\"><div class=\"kt-inside-inner-col\">\n<p><a href=\"https:\/\/www.sfb274.de\/en\/project\/c02\/\">Next Project  >><\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"project-area":[18],"class_list":["post-2460","project","type-project","status-publish","hentry","project-area-c-neuronal-checkpoints-of-cns-recovery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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