{"id":2466,"date":"2024-01-30T14:19:27","date_gmt":"2024-01-30T13:19:27","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2466"},"modified":"2024-09-20T11:13:35","modified_gmt":"2024-09-20T09:13:35","slug":"c03","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/c03\/","title":{"rendered":"Cellular and molecular checkpoints of circuit refinement following traumatic injuries of the CNS"},"content":{"rendered":"<style>.kb-row-layout-id2466_f34d81-6d > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2466_f34d81-6d > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2466_f34d81-6d > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2466_f34d81-6d > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2466_f34d81-6d > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2466_f34d81-6d > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2466_f34d81-6d alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2466_a48bc8-5e > .kt-inside-inner-col,.kadence-column2466_a48bc8-5e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2466_a48bc8-5e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2466_a48bc8-5e > .kt-inside-inner-col{flex-direction:column;}.kadence-column2466_a48bc8-5e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2466_a48bc8-5e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2466_a48bc8-5e{position:relative;}@media all and (max-width: 1024px){.kadence-column2466_a48bc8-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2466_a48bc8-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2466_a48bc8-5e\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>There is to date no therapy that prevents the devastating consequences of traumatic brain and spinal cord injuries. Previous work has shown that neuronal connections can spontaneously remodel after CNS injuries, a process that contributes to functional recovery. Here, we propose that the balance between adaptive and maladaptive neuronal remodeling depends on circuit refinement and is guided by the interplay between neuronal activity and microglia-driven synapse removal. We aim to identify the checkpoints for circuit refinement and reveal whether such checkpoints are maintained between different injury types and locations.<\/p>\n\n\n\n<p class=\"has-theme-palette-7-color has-text-color has-link-color wp-elements-840c8ec5ba7173e17b8ff9e526439e98\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/434476485\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2466_1bed49-8f > .kt-inside-inner-col,.kadence-column2466_1bed49-8f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2466_1bed49-8f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2466_1bed49-8f > .kt-inside-inner-col{flex-direction:column;}.kadence-column2466_1bed49-8f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2466_1bed49-8f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2466_1bed49-8f{position:relative;}@media all and (max-width: 1024px){.kadence-column2466_1bed49-8f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2466_1bed49-8f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2466_1bed49-8f\"><div class=\"kt-inside-inner-col\"><style>.kb-image2466_7b9ad7-71 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image2466_7b9ad7-71\"><img loading=\"lazy\" decoding=\"async\" width=\"1890\" height=\"1654\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2.png\" alt=\"\" class=\"kb-img wp-image-2390\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2.png 1890w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C03-Graphical-Abstract-Bareyre_V2-1536x1344.png 1536w\" sizes=\"auto, (max-width: 1890px) 100vw, 1890px\" \/><\/figure>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(50% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(10% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)));}.kb-row-layout-id2466_2f6c55-4a > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id2466_2f6c55-4a > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2466_2f6c55-4a alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2466_a6745d-07 > .kt-inside-inner-col,.kadence-column2466_a6745d-07 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2466_a6745d-07 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2466_a6745d-07 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2466_a6745d-07 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2466_a6745d-07 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2466_a6745d-07{position:relative;}@media all and (max-width: 1024px){.kadence-column2466_a6745d-07 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2466_a6745d-07 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2466_a6745d-07\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/www.sfb274.de\/en\/project\/c02\/\">&lt;&lt;  Previous Project<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2466_45ca30-ea > .kt-inside-inner-col,.kadence-column2466_45ca30-ea > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2466_45ca30-ea > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2466_45ca30-ea > .kt-inside-inner-col{flex-direction:column;}.kadence-column2466_45ca30-ea > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2466_45ca30-ea > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2466_45ca30-ea{position:relative;}@media all and (max-width: 1024px){.kadence-column2466_45ca30-ea > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2466_45ca30-ea > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2466_45ca30-ea\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\"><strong>|<\/strong><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2466_8249b7-0c > .kt-inside-inner-col,.kadence-column2466_8249b7-0c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2466_8249b7-0c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2466_8249b7-0c > .kt-inside-inner-col{flex-direction:column;}.kadence-column2466_8249b7-0c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2466_8249b7-0c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2466_8249b7-0c{position:relative;}@media all and (max-width: 1024px){.kadence-column2466_8249b7-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2466_8249b7-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2466_8249b7-0c\"><div class=\"kt-inside-inner-col\">\n<p><a href=\"https:\/\/www.sfb274.de\/en\/project\/c04\/\">Next Project  >><\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"project-area":[18],"class_list":["post-2466","project","type-project","status-publish","hentry","project-area-c-neuronal-checkpoints-of-cns-recovery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cellular and molecular checkpoints of circuit refinement following traumatic injuries of the CNS - SFB-Transregio 274<\/title>\n<meta name=\"description\" content=\"We propose the balance between adaptive 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