{"id":2474,"date":"2024-01-30T14:19:27","date_gmt":"2024-01-30T13:19:27","guid":{"rendered":"https:\/\/www.sfb274.de\/?post_type=project&#038;p=2474"},"modified":"2024-09-20T11:21:50","modified_gmt":"2024-09-20T09:21:50","slug":"c06","status":"publish","type":"project","link":"https:\/\/www.sfb274.de\/en\/project\/c06\/","title":{"rendered":"Understanding checkpoints of interneuron sculpting for neuronal remodelling of microcircuits to promote CNS repair\u00a0"},"content":{"rendered":"<style>.kb-row-layout-id2474_40861d-5e > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2474_40861d-5e > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2474_40861d-5e > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id2474_40861d-5e > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2474_40861d-5e > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2474_40861d-5e > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2474_40861d-5e alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col,.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2474_c1dfd6-10{position:relative;}@media all and (max-width: 1024px){.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2474_c1dfd6-10 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2474_c1dfd6-10\"><div class=\"kt-inside-inner-col\"><style>.kb-image2474_5b2c6f-2c .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image2474_5b2c6f-2c size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"823\" height=\"720\" src=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl-823x720.png\" alt=\"\" class=\"kb-img wp-image-2393\" srcset=\"https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl-823x720.png 823w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl-411x360.png 411w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl-768x672.png 768w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl-1536x1344.png 1536w, https:\/\/www.sfb274.de\/wp-content\/uploads\/2024\/01\/C06-Graphical-Abstract-Wahl.png 1890w\" sizes=\"auto, (max-width: 823px) 100vw, 823px\" \/><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column2474_4c3006-68 > .kt-inside-inner-col,.kadence-column2474_4c3006-68 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2474_4c3006-68 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2474_4c3006-68 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2474_4c3006-68 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2474_4c3006-68 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2474_4c3006-68{position:relative;}@media all and (max-width: 1024px){.kadence-column2474_4c3006-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2474_4c3006-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2474_4c3006-68\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>Strokes destroy excitatory inputs &#8211; not only in the stroke area, but also in remote regions such as the hippocampus, which may lead to disorganized GABAergic activity and cause cognitive decline. We propose here to identify and modulate checkpoints of GABAergic population dynamics shaping microcircuits of excitatory pyramidal neurons in the hippocampus. We aim at enhancing functional and structural rewiring processes by systematically modulating GABAergic interneuron activity and thus defining novel therapeutic targets for preventing cognitive decline after stroke.<\/p>\n\n\n\n<p class=\"has-text-align-right has-theme-palette-7-color has-text-color has-link-color wp-elements-06bcc4e4eb69ed9d32a35e1263fe4f86\"><a href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/533843335\" target=\"_blank\" rel=\"noreferrer noopener\">DFG GEPRIS<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(10% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)))minmax(0, calc(50% - ((var(--global-kb-gap-md, 2rem) * 2 )\/3)));}.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id2474_e5ca3b-c1 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2474_e5ca3b-c1 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col,.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col{flex-direction:column;}.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2474_7fd6b3-ad{position:relative;}@media all and (max-width: 1024px){.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2474_7fd6b3-ad > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2474_7fd6b3-ad\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/www.sfb274.de\/en\/project\/c05\/\">&lt;&lt;  Previous Project<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2474_13e473-20 > .kt-inside-inner-col,.kadence-column2474_13e473-20 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2474_13e473-20 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2474_13e473-20 > .kt-inside-inner-col{flex-direction:column;}.kadence-column2474_13e473-20 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2474_13e473-20 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2474_13e473-20{position:relative;}@media all and (max-width: 1024px){.kadence-column2474_13e473-20 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2474_13e473-20 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2474_13e473-20\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\"><strong>|<\/strong><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column2474_630833-7b > .kt-inside-inner-col,.kadence-column2474_630833-7b > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column2474_630833-7b > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2474_630833-7b > .kt-inside-inner-col{flex-direction:column;}.kadence-column2474_630833-7b > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column2474_630833-7b > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2474_630833-7b{position:relative;}@media all and (max-width: 1024px){.kadence-column2474_630833-7b > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column2474_630833-7b > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2474_630833-7b\"><div class=\"kt-inside-inner-col\">\n<p><a href=\"https:\/\/www.sfb274.de\/en\/project\/z01\/\">Next Project  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