• Sarah Jäkel Appointed W2 Professor

    Congratulations to Prof. Dr. Sarah Jäkel on accepting the W2 Professorship at the Department of Psychiatry and Psychotherapy (TUM Clinic Rechts der Isar) effective February 1, 2025. Well deserved!

  • TRR 274 Retreat 2024

    TRR 274 Retreat 2024 On 12 and 13 December, the annual TRR 274 Retreat took place at the Alte Mensa, Göttingen. During the retreat, the project leaders gave updates on their progress during the past year through a series of presentations. The Young Investigators were able to present their posters to all senior researchers for…

  • TRR 274 Young Investigator Retreat 2024

    TRR 274 Young Investigator Retreat 2024 On the 11th of December, the young investigators of the TRR 274 organized their first retreat of the second funding period at the Alte Mensa, Göttingen. Members of new projects finally had the chance to connect and integrate with our existing researchers. The Young Investigators presented their projects through…

  • APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

    Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques in the brain, contributing to neurodegeneration. The process by which these plaques form, particularly in sporadic (non-familial) cases of AD, remains not fully understood. Genetic studies have linked the apolipoprotein E (APOE) gene and microglial function—immune cells in the brain—to AD, suggesting…

  • Magdalena Götz Awarded the Bavarian Order of Merit

    TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder. Read the article written by the Helmholtz institute here. In our TRR, Magdalena Götz is project leader of project C05.

  • Microscopy course in Bordeaux

    Several members of our TRR 274 were co-organizing and teaching at the advanced imaging techniques course in Bordeaux from 30 Sept to 18 Oct 2024. Francesca Odoardi (co-director of the course, A04), Alexander Flügel (keynote speaker, A03), Arianna Merlini (Instructor, A04) & Michael Haberl (instructor, A03 and A04) could pass on their expertise on the…

  • CD8+ T cells drive inflammation in both prodromal and established MS

    Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression. Using single-cell RNA sequencing and T cell receptor analysis, scientists compared immune cells from identical twins, where one twin showed no symptoms or only early signs of neuroinflammation. CD8+ T cells in people…

  • International Summer School in Systems Neuroscience

    This years BmN / ELSC / ICL Summer School took place from 20 – 26 September 2024 in the stunning TUM cottage in Berchtesgaden. Organized by TRR 274 members Thomas Misgeld (Project B03 and C02) and Ruben Portugues (Project C04), with financial support from TRR 274.

  • Diversity Symposium at the BMC Munich

    Last week, the BMC Diversity Initiative held its first-ever diversity symposium, featuring three inspiring speakers who shared their career journeys and the challenges they’ve overcome to get where they are today. Speakers (from left to right): In research, diverse perspectives drive innovative ideas. Science thrives on curiosity and creativity,because the best answers are never straightforward….

  • TFEB governs B-lymphoid fate decisions.

    TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions Antigenic stimulation triggers TFEB to move into the nucleus, where it can either promote B cell survival or lead to apoptosis depending on T cell help. Without T cell support, TFEB increases pro-apoptotic proteins, leading to cell death. But with T…