Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques in the brain, contributing to neurodegeneration. The process by which these plaques form, particularly in sporadic (non-familial) cases of AD, remains not fully understood. Genetic studies have linked the apolipoprotein E (APOE) gene and microglial function—immune cells in the brain—to AD, suggesting…
TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder. Read the article written by the Helmholtz institute here. In our TRR, Magdalena Götz is project leader of project C05.
Visit the stand of the Network of German Neurocenters at Neuroscience 2024 from 5 – 9 October in Chicago, IL, USA. http://www.neurocenters-germany.de/
Several members of our TRR 274 were co-organizing and teaching at the advanced imaging techniques course in Bordeaux from 30 Sept to 18 Oct 2024. Francesca Odoardi (co-director of the course, A04), Alexander Flügel (keynote speaker, A03), Arianna Merlini (Instructor, A04) & Michael Haberl (instructor, A03 and A04) could pass on their expertise on the…
Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression. Using single-cell RNA sequencing and T cell receptor analysis, scientists compared immune cells from identical twins, where one twin showed no symptoms or only early signs of neuroinflammation. CD8+ T cells in people…
This years BmN / ELSC / ICL Summer School took place from 20 – 26 September 2024 in the stunning TUM cottage in Berchtesgaden. Organized by TRR 274 members Thomas Misgeld (Project B03 and C02) and Ruben Portugues (Project C04), with financial support from TRR 274.
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
Last week, the BMC Diversity Initiative held its first-ever diversity symposium, featuring three inspiring speakers who shared their career journeys and the challenges they’ve overcome to get where they are today. Speakers (from left to right): In research, diverse perspectives drive innovative ideas. Science thrives on curiosity and creativity,because the best answers are never straightforward….
TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions Antigenic stimulation triggers TFEB to move into the nucleus, where it can either promote B cell survival or lead to apoptosis depending on T cell help. Without T cell support, TFEB increases pro-apoptotic proteins, leading to cell death. But with T…
A recent study published in Nature Neuroscience reveals that oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in energy metabolism by utilizing fatty acids to support white matter function. This continuous lipid metabolism provides an energy reserve essential for maintaining axonal health, especially during glucose scarcity. Key Findings: Implications:…
Congratulations to Anna-Sophia Wahl for obtaining a European Research Council (ERC) Starting Grant! From the Ludwig-Maximilians-Universität München Newsroom:“In the ARISE (Activate Repair In StrokE) project, Anna-Sophia Wahl wants to discover fundamental principles how the brain orchestrates the cellular response [to launch self-repair mechanisms after damage] and how it can be further improved. Using state- of the art…
After her outstanding contributions to research and teaching, our project leader Florence Bareyre has been awarded an adjunct professorship.
