CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation
Background Regulatory T (Treg) cells expressing the transcription factor Foxp3 are essential for maintaining immune tolerance and preventing autoimmunity. While their systemic immunosuppressive role is well established, less is understood about how Treg cells function within specific tissues after inflammation resolves. In autoimmune diseases affecting the central nervous system (CNS), such as multiple sclerosis, inflammation…





