• CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation

    Background Regulatory T (Treg) cells expressing the transcription factor Foxp3 are essential for maintaining immune tolerance and preventing autoimmunity. While their systemic immunosuppressive role is well established, less is understood about how Treg cells function within specific tissues after inflammation resolves. In autoimmune diseases affecting the central nervous system (CNS), such as multiple sclerosis, inflammation…

  • Welcome to the new coordinator: Camilla!

    We are pleased to announce the handover of the coordination of TRR 274. As of January 30 2026, Camilla Giudici has taken over the coordination role from Adinda Wens. We sincerely thank Adinda for her dedication, commitment, and many years of coordination, which have contributed to the success and cohesion of the consortium. We warmly…