Summary
Erythropoietin (EPO) is a cytokine that serves, independent of hematopoiesis, signalling functions within the brain, where EPO and its receptor are upregulated upon injury. The underlying mechanisms, however, have remained obscure. We aim to understand the roles of EPO/EPOR signalling as checkpoints of brain homeostasis and thereby specifically predict effects of recombinant EPO as a neuroprotective drug. To this end, we will explore the induction/expression of EPO and EPOR at the single cell level with novel reporter mice and test the recovery of cell specific Epo/Epor mutants from acute and chronic brain injury.
