TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation
Background Autoimmune inflammation in the central nervous system (CNS), such as in multiple sclerosis (MS), causes varying outcomes largely influenced by complex interactions among resident glial
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ERC Advanced Grant for Thomas Korn
Congratulations to Thomas Korn for obtaining a European Research Council ERC Advanced Grant! With his project BREAKING BAD, Thomas Korn will explore a critical question at
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Francesca Odoardi Appointed W3 Professor
Congratulations to Prof. Dr. Francesca Odoardi on accepting the W3 Professorship for Cellular and Molecular Imaging of Neuroimmunological Processes effective March 15, 2025. Well deserved!
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Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
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Sarah Jäkel Appointed W2 Professor
Congratulations to Prof. Dr. Sarah Jäkel on accepting the W2 Professorship at the Department of Psychiatry and Psychotherapy (TUM Clinic Rechts der Isar) effective February 1,
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APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques in the brain, contributing to neurodegeneration. The process by which these plaques form,
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Magdalena Götz Awarded the Bavarian Order of Merit
TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder.Read the article written by the Helmholtz
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Microscopy course in Bordeaux
Several members of our TRR 274 were co-organizing and teaching at the advanced imaging techniques course in Bordeaux from 30 Sept to 18 Oct 2024. Francesca
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CD8+ T cells drive inflammation in both prodromal and established MS
Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression.Using single-cell RNA sequencing and
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BCAS1+ oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
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TFEB governs B-lymphoid fate decisions.
TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions Antigenic stimulation triggers TFEB to move into the nucleus, where it can
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Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
A recent study published in Nature Neuroscience reveals that oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in energy metabolism
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