APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

    Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques in the brain, contributing to neurodegeneration. The process by which these plaques form,

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    Magdalena Götz Awarded the Bavarian Order of Merit

    TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder.Read the article written by the Helmholtz

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    Neuroscience 2024

    Network of German Neurocenters @ SfN 2024

    Visit the stand of the Network of German Neurocenters at Neuroscience 2024 from 5 – 9 October in Chicago, IL, USA. http://www.neurocenters-germany.de/

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    Microscopy course in Bordeaux

    Several members of our TRR 274 were co-organizing and teaching at the advanced imaging techniques course in Bordeaux from 30 Sept to 18 Oct 2024. Francesca

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    CD8+ T cells drive inflammation in both prodromal and established MS

    Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression.Using single-cell RNA sequencing and

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    International Summer School in Systems Neuroscience

    This years BmN / ELSC / ICL Summer School took place from 20 – 26 September 2024 in the stunning TUM cottage in Berchtesgaden. Organized by

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    BCAS1+ oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

    BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

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    BMC Diversity Symposium 2024

    Diversity Symposium at the BMC Munich

    Last week, the BMC Diversity Initiative held its first-ever diversity symposium, featuring three inspiring speakers who shared their career journeys and the challenges they’ve overcome to

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    Fig. 9: Proposed mechanisms by which TFEB governs B-lymphoid fate decisions.

    TFEB governs B-lymphoid fate decisions.

    TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions Antigenic stimulation triggers TFEB to move into the nucleus, where it can

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    Oligodendroglial glucose starvation leads to a gradual myelin loss.

    Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

    A recent study published in Nature Neuroscience reveals that oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in energy metabolism

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    ERC Starting Grant for Anna-Sophia Wahl

    Congratulations to Anna-Sophia Wahl for obtaining a European Research Council (ERC) Starting Grant! From the Ludwig-Maximilians-Universität München Newsroom:”In the ARISE (Activate Repair In StrokE) project, Anna-Sophia Wahl wants

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    Florence Bareyre

    Congratulations Professor Bareyre!

    After her outstanding contributions to research and teaching, our project leader Florence Bareyre has been awarded an adjunct professorship.

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