CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation
Background Regulatory T (Treg) cells expressing the transcription factor Foxp3 are essential for maintaining immune tolerance and preventing autoimmunity. While their systemic immunosuppressive role is well
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Welcome to the new coordinator: Camilla!
We are pleased to announce the handover of the coordination of TRR 274. As of January 30 2026, Camilla Giudici has taken over the coordination role
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ERC Consolidator Grant for Arthur Liesz
Congratulations to our member Arthur Liesz on receiving an European Research Council (ERC) Consolidator Grant!With his ERC project TRAINED, Arthur will study how the immune system
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SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis
Background In Multiple Sclerosis (MS), focal lesions and white matter pathology have been long studied. Grey matter changes however, particularly in the cortex, are increasingly recognised
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TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation
Background Autoimmune inflammation in the central nervous system (CNS), such as in multiple sclerosis (MS), causes varying outcomes largely influenced by complex interactions among resident glial
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ERC Advanced Grant for Thomas Korn
Congratulations to Thomas Korn for obtaining a European Research Council ERC Advanced Grant! With his project BREAKING BAD, Thomas Korn will explore a critical question at
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Francesca Odoardi Appointed W3 Professor
Congratulations to Prof. Dr. Francesca Odoardi on accepting the W3 Professorship for Cellular and Molecular Imaging of Neuroimmunological Processes effective March 15, 2025. Well deserved!
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Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
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Sarah Jäkel Appointed W2 Professor
Congratulations to Prof. Dr. Sarah Jäkel on accepting the W2 Professorship at the Department of Psychiatry and Psychotherapy (TUM Clinic Rechts der Isar) effective February 1,
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APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques in the brain, contributing to neurodegeneration. The process by which these plaques form,
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Magdalena Götz Awarded the Bavarian Order of Merit
TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder.Read the article written by the Helmholtz
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Microscopy course in Bordeaux
Several members of our TRR 274 were co-organizing and teaching at the advanced imaging techniques course in Bordeaux from 30 Sept to 18 Oct 2024. Francesca
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