Author: Camilla Giudici

  • CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation

    Background Regulatory T (Treg) cells expressing the transcription factor Foxp3 are essential for maintaining immune tolerance and preventing autoimmunity. While their systemic immunosuppressive role is well established, less is understood about how Treg cells function within specific tissues after inflammation resolves. In autoimmune diseases affecting the central nervous system (CNS), such as multiple sclerosis, inflammation…

  • Welcome to the new coordinator: Camilla!

    We are pleased to announce the handover of the coordination of TRR 274. As of January 30 2026, Camilla Giudici has taken over the coordination role from Adinda Wens. We sincerely thank Adinda for her dedication, commitment, and many years of coordination, which have contributed to the success and cohesion of the consortium. We warmly…

  • ERC Consolidator Grant for Arthur Liesz

    Congratulations to our member Arthur Liesz on receiving an European Research Council (ERC) Consolidator Grant! With his ERC project TRAINED, Arthur will study how the immune system can develop a long-lasting “memory” after injuries like stroke. This trained immunity can become dysregulated and drive chronic inflammation throughout the body, long after the initial injury. Read…

  • TRR 274 Retreat 2025

    TRR 274 Annual Retreat in San Servolo, Venice On 29–30 October, the TRR 274 community gathered for our annual retreat on the island of San Servolo in Venice, Italy. Over two days, project leaders and early career researchers shared progress from the past year through a series of engaging presentations. A dedicated PI meet and…

  • SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis

    Background In Multiple Sclerosis (MS), focal lesions and white matter pathology have been long studied. Grey matter changes however, particularly in the cortex, are increasingly recognised as strong predictors of progression, disability and cognitive decline. In-vivo detection of cortical synapse loss, an early indicator of grey matter pathology, has remained challenging. Aims The study set…

  • TRR 274 brings Brain Recovery Research to life at the Göttingen Night of Science

    Great interest at our stand! Visitors of all ages explored our interactive exhibits and learned more about brain recovery research. On the evening of June 21, from 5 p.m. until midnight, researchers from the TRR 274 (Institute of Multiple Sclerosis Research (IMSF) and the Institute of Neuropathology) invited visitors of all ages to explore how…

  • TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

    Background Autoimmune inflammation in the central nervous system (CNS), such as in multiple sclerosis (MS), causes varying outcomes largely influenced by complex interactions among resident glial cells (microglia, astrocytes), infiltrating immune cells, and the blood–brain barrier. Understanding the endogenous mechanisms that drive inflammation resolution and tissue repair is essential, but these CNS-intrinsic pathways remain poorly…

  • ERC Advanced Grant for Thomas Korn

    Congratulations to Thomas Korn for obtaining a European Research Council ERC Advanced Grant! With his project BREAKING BAD, Thomas Korn will explore a critical question at the intersection of immunology and neuroscience:Why do some T cells turn against the body and trigger diseases like neuromyelitis optica, and could similar immune mechanisms also play a role…

  • TRR 274 at Munich Brain Day 2025

    The TRR 274 was proud to once again sponsor the Munich Brain Day, now in its third edition — a fantastic initiative to connect and strengthen the neuroscience community in Munich. Co-organized by TRR project leader Ruben Portugues (Project C04), this year’s event featured insightful talks by Jovica Ninkovic (Project B05) and Thomas Misgeld (TP…

  • Network of German Neurocenters @ SONA 2025

    From April 17–20, 2025, TRR 274 was represented at the booth of the Network of German Neuroscience Centers during the 17th International Conference of the Society of Neuroscientists of Africa (SONA) in Marrakesh, Morocco. For what was likely the first time, a country showcased its national neuroscience research landscape at an African neuroscience conference. The…